Publications

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In Press

  • Blair MA, Nitzburg G, DeRosse P, Karlsgodt KH: Relationship between executive function, attachment style, and psychotic like experiences in typically developing youth, Schizophrenia Research, in press (epub ahead of print)
  • Ikuta T, Del Arco A, Karlsgodt KH: White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity, Brain Imaging and Behavior, in press (epub ahead of print)
  • Prendergast DM, Karlsgodt KH, Fales CL, Ardekani BA, Szeszko PR: Corpus callosum shape and morphology in youth across the psychosis spectrum, Schizophrenia Research, in press (epub ahead of print)

2018

  • Karlsgodt KH, Bato AA, Ikuta T, Peters BD, DeRosse P, Szeszko PR, Malhotra AK: Brain activation during a cognitive control task in youth with high internalizing or externalizing behavior, Biological Psychiatry:CCNI, 3(2):133-140
  • Lyall AE, Pasternak O, Robinson DGT, Newell D, Trampush JW, Gallego JA, Fava M, Malhotra AK, Karlsgodt KH, Kubicki M, Szeszko PR: Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning. Molecular Psychiatry, 23(3):701-707, 2018
  • Uddin LQ, Karlsgodt KH: Future directions for examination of brain networks in neurodevelopmental disorders, Journal of Clinical Child and Adolescent Psychology, 10:1-15, 2018 (invited review)
  • Barber AD, Lindquist MA, DeRosse P, Karlsgodt KH: Dynamic neural states reflecting sub-clinical psychotic experiences, Biological Psychiatry: CCNI, 3(5): 443-453, 2018

2017

  • Schreiner M, Forsyth JK, Karlsgodt KH, Anderson AE, Hirsh N, Kushan L, Uddin LQ, Mattiacio L, Coman IL, Kates WR, Bearden CE. Intrinsic Connectivity Network-Based Classification and Detection of Psychotic Symptoms in Youth With 22q11.2 Deletions. Cereb Cortex. 27(6):3294-3306, 2017
  • DeRosse P, Ikuta T, Karlsgodt KH, Peters BD, Gopin CB, Szeszko PR, MalhotraAK. White Matter Abnormalities Associated With Subsyndromal Psychotic-LikeSymptoms Predict Later Social Competence in Children and Adolescents. Schizophr Bull. 43(1):152-159, 2017
  • Eckfield AS, Karlsgodt KH, Haut K, Bachman P, Jalbrzikowski M, Zinberg J, van Erp TGM, Cannon TD, Bearden CE: Disrupted working memory circuitry in early onset psychosis, Frontiers in Human Neuroscience 11:394, 2017
  • Ibrahim AFA, Montojo C, Haut K, Karlsgodt KH, Hansen L, Congdon E, Rosser T, Bilder RM, Silva AJ, Bearden CE: Spatial working memory in Neurofibromatosis-1: Altered neural activity and functional connectivity, Neuroimage: Clinical, 15: 801-811, 2017
  • Sarpal DK, Robinson DG, Fales C, Lencz T, Argyelan M, Karlsgodt KH, Gallego JA, John M, Kane JM, Szeszko PR, Mahotra AK: Relationship between duration of untreated psychosis and intrinsic cortico-striatal connectivity in patients with early phase schizophrenia. Neuropsychopharmacology, 42(11):2214-2221, 2017

2016

  • Nitzburg GC, Gopin CB, Peters BD, Karlsgodt KH, Malhotra AK, DeRosse P: The relationship between temperament and character and psychotic-like experiences in healthy children and adolescents, European Psychiatry, 31:60-5, 2016
  • Poldrack RA, Congdon E, Triplett W, Gorgolewski KJ, Karlsgodt KH, Mumford JA, Sabb FW, Freimer NB, London ED, Cannon TD, Bilder RM. A phenome-wide examination of neural and cognitive function. Sci Data. 3:160110, 2016
  • Chang EH, Argyelan M, Aggarwal M, Chandon TS, Karlsgodt KH, Mori S, Malhotra AK. The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains. Neuroimage. 147:253-261, 2016
  • Chang EH, Argyelan M, Aggarwal M, Chandon TS, Karlsgodt KH, Mori S, Malhotra AK. Diffusion tensor imaging measures of white matter compared to myelin basic protein immunofluorescence in tissue cleared intact brains. Data Brief 10:438-443, 2016
  • Sarpal DK, Argyelan M, Robinson D, Szeszko PR, Karlsgodt KH, John M, Weissman N, Gallego JA, Kane JM, Lencz T, Malhotra AK: Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment, American Journal of Psychiatry, 173(1): 69-77, 2016
  • Karlsgodt KH: Diffusion Tensor Imaging in Schizophrenia: Progress and Future Directions, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(3):209-17, 2016
  • Schwehm A, Robinson DG, Gallego JA, Karlsgodt KH, Ikuta T, Peters BD, Malhotra AK: Age and sex effects on white matter tracts in psychosis from adolescence through adulthood, Neuropsychopharmacology, 41(10):2473-80, 2016

2015

  • Karlsgodt KH, John M, Ikuta T, Rigoard P, Peters BD, DeRosse P, Malhotra AK, Szeszko PR: The accumbofrontal tract: Diffusion tensor imaging characterization and developmental changes from childhood to adulthood, submitted, Human Brain Mapping, 36(12): 4954-63, 2015
  • Ikuta T, DeRosse P, Argyelan M, Karlsgodt KH, Kingsley PB, Szeszko PR, Malhotra AK: Subcortical Modulation in Auditory Processing and Auditory Hallucinations, Behavioral Brain Research, 295: 78-81, 2015
  • Karlsgodt, KH: Working Memory, in Brain Mapping: An Encyclopedic Reference, Ed, Arther Toga, Ph.D. Elsevier, 2015
  • Spiegel S, Chiu A, James AS, Jentsch JD, Karlsgodt KH: Similar recognition memory deficits in mice caused by null mutation of genes coding for BLOC-1 complex subunits pallidin and dysbindin, Genes Brains and Behavior, 14(8): 618-24, 2015
  • Sarpal D, Robinson D, Lencz T, Argyelan M, Ikuta T, Karlsgodt KH, Kane JM, Szeszko PR, Malhotra AK: Antipsychotic treatment and functional connectivity of the striatum: A prospective, controlled study in first-episode schizophrenia, JAMA Psychiatry, 72(1):5-13, 2015
  • DeRosse P, Karlsgodt KH: Examining the Psychosis Continuum, Curr Behav Neuroscience Reports, 2(2):80-89.
  • Karlsgodt KH, Bato AA, Blair AA, DeRosse P, Szeszko PR, Malhotra AK: White matter microstructure in the executive network associated with aggression in healthy adolescents and young adults, Social Cognitive and Affective Neuroscience, 10(9): 1251-6, 2015
  • Haut KM, Karlsgodt KH, Bilder RM, Congdon E, Freimer N, London ED, Sabb FW, Ventura J, Cannon TD: Memory systems in schizophrenia: Modularity is preserved but deficits are generalized, Schizophrenia Research, 168(1-2): 223-30, 2015
  • Montojo CA, Jarbrzikowski M, Congdon E, Domicoli S, Chow C, Dawson C, Karlsgodt KH, Bilder RM, Bearden CE: Neural substrates of inhibitory control deficits in 22q11.2 deletion syndrome, Cereb Cortex, 25(4):1069-79, 2015
  • Peters BD, Karlsgodt KH: White matter development in the early stages of psychosis, Schizophrenia Research, 161(1):61-9, 2015

2014

  • DeRosse P, Ikuta T, Peters BD, Karlsgodt KH, Szeszko PR, Malhotra AK: Adding insult to injury: Childhood and adolescent risk factors for psychosis predict lower fractional anisotropy in the superior longitudinal fasciculus in healthy adults, Psychiatry Research , 224(3):296-302, 2014
  • Jalbrzikowski M, Villalon-Reina JE, Karlsgodt KH, Senturk D, Chow C, Thompson PM, Bearden CE: Altered white matter microstructure is associated with social cognition and psychotic symptoms in 22q11.2 microdeletion syndrome, Frontiers in Behavioral Neuroscience, 8, 393, 2014
  • Congdon E, Altshuler LL, Mumford JA, Karlsgodt KH, Sabb FW, Ventura J, McGough JJ, London ED, Cannon TD, Bilder RM, Poldrack RA: Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: Preliminary findings on the effects of medication and symptom severity, Psychiatry Research, 222(1-2): 17-28, 2014
  • Ikuta T, Peters BD, Guha S, John M, Karlsgodt KH, Lencz T, Szeszko PR, Malhotra AK: A schizophrenia risk gene, ZNF804A, is associated with brain white matter microstructure, Schizophrenia Research, 155(1-3):15-20, 2014
  • Karlsgodt KH, van Erp TGM, Bearden CE, Cannon TD: Altered age-related trajectories in functional brain activation in healthy adolescents and those at risk for psychosis, Psychiatry Research: Neuroimaging, 221(1):21-9, 2014
  • Peters BD, Voineskos AN, Szeszko PR, Lett TA, DeRosse P, Guha S, Karlsgodt KH, Ikuta T, Felsky D, John M, Kennedy JL, Lencz T, Malhotra AM: Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids, Journal of Neuroscience, 34(18):6367-76, 2014
  • White CN, Congdon E, Mumford JA, Karlsgodt KH, Sabb FW, Freimer NB, London ED, Cannon TD, Bilder RM, Poldrack RA: Decomposing decision components in the stop-signal task: A model-based approach to individual differences in inhibitory control, in press, Journal of Cognitive Neuroscience, 26(8):1601-44
  • Montojo, CA, Ibrahim A, Karlsgodt KH, Chow C, Hilton AE, Jonas RK, Vesagas TK, Bearden CE: Disrupted working memory circuitry and psychotic symptoms in 22q11.2 deletion syndrome, Neuroimage: Clinical 4:392-402, 2014
  • Helfinstein SM, Schonberg T, Congdon E, Karlsgodt KH, Mumford JA, Sabb FW, Cannon TD, London ED, Bilder RM, Poldrack RA: Predicting risky choices from brain activity patterns, Proceedings of the National Academy of Sciences:111(7):2470-5, 2014

2013

  • Congdon E, Bato AA, Schonberg T, Mumford JA, Karlsgodt KH, Sabb FW, London ED, Cannon TD, Bilder RM, Poldrack RA: Differences in Neural Activation as a Function of Risk-taking Task Parameters, Frontiers in Decision Neuroscience, 7:173. doi: 10.3389/fnins.2013.00173, 2013
  • Schreiner MJ, Karlsgodt KH, Uddin LQ, Chow C, Congdon E, Jalbrzikowski M, Bearden CE: Default mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome, Social Cognitive and Affective Neuroscience, 2013

2012

  • Karlsgodt KH, Rosser T, Lutkenhoff ES, Cannon TD, Silva AC, Bearden CE: Alterations in white matter microstructure in Neurofibromatosis-1, PLoS-One, 7(10), 2012
  • Lutkenhoff E*, Karlsgodt KH*, Stein J, Thompson P, Cannon TD, Jentsch JD, Structural and functional neuroimaging phenotypes in dysbindin mutant mice, Neuroimage 62(1):120-9, 2012
  • Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T, Woods SW, Addington J, Cadenhead KS, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Cannon TD; on behalf of the NAPLS Consortium. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study, Schizophrenia Research, 134(1):1-9, 2012
  • Karlsgodt KH, Jacobson SC, Seal M, Fusar-Poli, P: The Relationship of Developmental Changes in White Matter to the Onset of Psychosis. Current Pharmaceutical Design, 18(4):422-32, 2012
  • Bearden CE, Karlsgodt KH, Bachman P, van Erp TG, Winkler AM, Glahn DC: Genetic Architecture of Declarative Memory: Implications for Complex Illnesses. Neuroscientist, 18(5)516-32, 2012

2011

  • Kochunov P, Glahn DC, Lancaster J, Winkler A, Karlsgodt KH, Olvera RL, Curran JE, Carless MA, Dyer TD, Almasy L, Duggirala R, Fox PT, Blangero J, Blood Pressure and Cerebral White Matter Share Common Genetic Factors in Mexican Americans, Hypertension, 57(2): 330-5, 2011
  • Karlsgodt KH*, Robleto K*, Trantham-Davidson H*, Jairl C, Cannon TD, Lavin A**, Jentsch JD**: Reduced dysbindin expression mediates NMDA receptor hypofunction and impaired working memory performance, Biological Psychiatry, 69: 28-34, 2011
  • Karlsgodt KH, Ellman LM, Sun D, Mittal V, Cannon TD: The Neurodevelopmental Hypothesis of Schizophrenia, in Schizophrenia: The Final Frontier- Festschrift for Robin M. Murray, Eds A.S David , P McGuffin, S Kapur, Psychology Press, 2011
  • Karlsgodt KH, Bachman P, Winkler AM, Bearden CE, Glahn DC: Genetic influence on the working memory circuitry: Behavior, structure, function, and extension to illness. Behavioural Brain Research, 225(2)610-22, 2011

2010

  • Mittal VA, Karlsgodt KH, Zinberg J, Cannon TD, Bearden CE: Identification and treatment of a pineal region tumor in an adolescent with prodromal psychotic symptoms, American Journal of Psychiatry, 167(9):1033-7, 2010
  • Karlsgodt KH, Kochunov P, Winkler AM, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC: A multimodal assessment of the genetic control over working memory, Journal of Neuroscience, 30(24) 8197-202, 2010
  • Shilyansky C, Karlsgodt KH, Cummings D, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ: Neurofibromin regulates corticostriatal inhibitory networks during working memory performance, Proceedings of the National Science Academy, 107(29)13141-6, 2010
  • Karlsgodt KH, Sun D, Cannon TD: Structural and Functional Brain Abnormalities in Schizophrenia, Current Directions in Psychological Science, 19(4) 226-231, 2010

2009

  • Karlsgodt KH, Niendam TA, Bearden CE, Cannon TD: White Matter Integrity and Prediction of Social and Role Functioning in Subjects at Ultra-High Risk for Psychosis, Biological Psychiatry, 66(6):562-9, 2009.
  • Sanz JH, Karlsgodt KH, Bearden CE, van Erp TGM, Nandy RR, Ventura J, Nuechterlein KH, Cannon TD: Symptomatic and Functional Correlates of Regional Brain Physiology During Working Memory Processing in Patients with Recent Onset Schizophrenia, Psychiatry Research, 173(3):177-82, 2009
  • Karlsgodt KH, Sanz J, van Erp TGM, Bearden CE, Nuechterlein KH, Cannon TD: Re-Evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia, Schiz Research, 108(1-3):143-150, 2009

2008

  • van Erp TGM, Lesh TA, Knowlton BJ, Bearden CE, Hardt M, Karlsgodt KH, Shirinyan D, Rao V, Green MF, Subotnik KL, Nuechterlein K, Cannon TD: Remember and know judgments during recognition in chronic schizophrenia, Schizophrenia Research, 100(1-3): 181-190, 2008.
  • Karlsgodt KH, van Erp TGM, Poldrack RA, Bearden CE, Nuechterlein KH, Cannon TD: Diffusion Tensor Imaging of the Superior Longitudinal Fasciculus and Working Memory in Patients with Recent-Onset Schizophrenia, Biological Psychiatry, 63(5): 512-8, 2008.
  • Karlsgodt KH, Sun D, Jiminez AM, Lutkenhoff ES, Willhite R, van Erp TGM, Cannon TD: Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia, Development and Psychopathology, 20(4): 1297-327, 2008

2007

  • Yamamoto RT, Karlsgodt KH, Rott D, Lukas SE, Elman I: Effects of perceived cocaine availability on subjective and objective responses to the drug, Substance Abuse Treatment Prevention Policy, 2(30), 2007
  • Karlsgodt KH, Glahn DC, van Erp TG, Therman S, Huttunen M, Manninen M, Kaprio J, Cohen MS, Lonnqvist J, Cannon TD.: The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects, Schizophrenia Research, 89(1-3): 191-7, 2007.

2005

  • Cannon TD, Glahn DC, Kim J, Van Erp TGM, Karlsgodt KH, Cohen MS, Nuechterlein KH, Bava S, Shirinyan D.: Dorsolateral Prefrontal Cortex Activity During Maintenance and Manipulation Of Information in Working Memory in Patients with Schizophrenia, Archives of General Psychiatry, 62(10): 1071-80, 2005
  • Karlsgodt KH, Shirinyan D, van Erp TGM, Cohen MS, Cannon TD: Hippocampal involvement in working memory encoding and retrieval, Neuroimage 25(4): 1224-31, 2005.

2004

  • Hopper JW, Karlsgodt KH, Adler CM, Macklin EA, Lukas SE, Elman I: Effects of acute cortisol administration on attention, recall, and recognition task performance in individuals with cocaine dependence, Human Psychopharmacology 19(7): 511-6, 2004.

2003

  • Elman I, Lucas SE, Karlsgodt KH, Gasic GP, Breiter HC: Acute cortisol administration triggers craving in individuals with cocaine dependence, Psychopharmacology Bulletin, 37(3): 84-9, 2003
  • Karlsgodt KH, Lukas SE, Elman I: Psychosocial Stress and the Duration of Cocaine Use in Non-Treatment Seeking Individuals with Cocaine Dependence, American Journal of Drug and Alcohol Abuse, 29(3): 539-51, 2003

2002

  • Elman I, Karlsgodt KH, Gastfriend DR, Chabris CF, Breiter HC: Cocaine-Primed Craving and its Relationship to Depressive Symptomatology in Individuals with Cocaine Dependence. J Psychopharmacology 16(2):163-167, 2002

2001

  • Elman I, Krause S, Karlsgodt KH, Schoenfeld DA, Gollub RL, Breiter HC, Gastfriend DR.: Clinical outcomes following cocaine infusion in non treatment-seeking individuals with cocaine dependence. Biological Psychiatry. 49(6):553-5, 2001
  • Elman, I., Karlsgodt, KH, Gastfriend, DR.: Gender differences in cocaine craving among non-treatment-seeking individuals with cocaine dependence. Am J Drug Alcohol Abuse 27(2):193-202, 2001